夏宁邵教授  
所在科室:检验科
最高学位:
硕导/博导:博导
Email:
教育与工作经历
1981~1995年,湖南娄底地区人民医院传染科住院医师、主治医师、副主任医师;1986~1987年,同济医科大学附属同济医院进修;1990~1995年,中国预防医学科学院病毒所进修;1995年至今,澳门新萄京客户端下载生命科学学院副研究员、研究员、教授、博导;1996年,香港大学医学院微生物学系访问学者;2005年至今,国家传染病诊断试剂与疫苗工程技术研究中心(澳门新萄京客户端下载)主任;2011年至今,澳门新萄京客户端下载公共卫生学院院长、教授;2013年至今,分子疫苗学和分子诊断学国家重点实验室(澳门新萄京客户端下载)主任、澳门新萄京客户端下载-app手机版网址8522cm医学诊断中心主任、医学检验科主任。
研究方向与科研项目
研究方向:医学病毒相关基因工程抗原、诊断试剂、疫苗、单克隆抗体等研发和产业化以及相关的分子病毒学、免疫学基础研究。先后主持国家科技重大专项、863计划、国家科技支撑计划、国际科技合作项目、国家自然科学基金(杰出青年基金、重点项目)、福建省科技重大专项、厦门市科技重大专项等国家、省、市重大重点课题,累计主持纵向课题48项。主要承担项目:1、国家自然科学基金杰出青年科学基金项目:病毒性传染病疫苗及血清学分子基础研究(编号:30925030) 2、国家自然科学基金重点项目:多聚化抗原诱导高效体液免疫应答的机制研究(编号:31730029)3、863计划:流感病毒适用的抗原快速诊断试剂盒(免疫渗滤法)及关键原料的研制(编号:2010AA022801)4、国家“十五”重大科技专项“创新药物与中药现代化”项目:重组戊型肝炎疫苗临床研究及产业化(编号:2005AA2Z3H20)5、重大新药创制国家科技重大专项:重组尖锐湿疣疫苗Ⅰ-Ⅲ临床试验(编号:2015ZX09101034)6、国家自然科学基金国际合作项目:单克隆抗体中和呼吸道合胞病毒的结构基础(编号:81361120408)7、国家自然科学基金国际(地区)合作两岸交流项目:慢性乙型肝炎治疗新标识:乙型肝炎病毒核心抗体的临床意义及免疫机制(编号:81261160322)。
学术成果与获奖情况
在New England Journal of Medicine、Lancet、Science Translational Medicine、Science Advances、Nature Microbiology、Nature Communications、PNAS、Science、Nature等刊物发表SCI论文300余篇,总被引4000余次。2014~2018年连续五年入选Elsevier中国高被引学者榜单(医学领域)。代表性论文:1、Jun Zhang#*, Xue-Feng Zhang#, Shou-Jie Huang, Ting Wu, Yue-Mei Hu, Zhong-Ze Wang, Hua Wang, Han-Min Jiang, Yi-Jun Wang, Qiang Yan, Meng Guo, Xiao-Hui Liu, Jing-Xin Li, Chang-Lin Yang, Quan Tang, Ren-Jie Jiang, Hui-Rong Pan, Yi-Min Li, J. Wai-Kuo Shih, Mun-Hon Ng, Feng-Cai Zhu*, Ning-Shao Xia*. Long-Term Efficacy of a Hepatitis E Vaccine. New England Journal of Medicine, 2015; 372(10):914-922. 2、Feng-Cai Zhu#, Jun Zhang#, Xue-Feng Zhang, Chen Zhou, Zhong-Ze Wang, Shou-Jie Huang, Hua Wang, Chang-Lin Yang, Han-Min Jiang, Jia-Ping Cai, Yi-Jun Wang, Xing Ai, Yue-Mei Hu, Quan Tang, Xin Yao, Qiang Yan, Yang-Ling Xian, Ting Wu, Yi-Min Li, Ji Miao, Mun-Hon Ng, James Wai-Kuo Shih, Ning-Shao Xia*. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet, 2010; 376:895-902. 3、Lunzhi Yuan#, Jing Jiang#, Xuan Liu#, Yali Zhang, Liang Zhang, Jiaojiao Xin, Kun Wu, Xiaoling Li, Jiali Cao, Xueran Guo, Dongyan Shi, Jun Li, Longyan Jiang, Suwan Sun, Tengyun Wang, Wangheng Hou, Tianying Zhang, Hua Zhu, Jun Zhang, Quan Yuan, Tong Cheng*, Jun Li*, Ningshao Xia*. HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation. Gut, 2019.(Online). 4、Tian-Ying Zhang#, Quan Yuan#*, Jing-Hua Zhao, Ya-Li Zhang, Lun-Zhi Yuan, Ying Lan, Yu-Chieh Lo, Chen-Pu Sun, Chang-Ru Wu, Jun-Fang Zhang, Ying Zhang, Jia-Li Cao, Xue-Ran Guo, Xuan Liu, Xiao-Bing Mo, Wen-Xin Luo, Tong Cheng, Yi-Xin Chen, Mi-Hua Tao, James WK Shih, Qin-Jian Zhao, Jun Zhang, Pei-Jer Chen, Y Adam Yuan*, Ning-Shao Xia*. Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen. Gut, 2016; 65:658-671. 5、Quan Yuan#, Liu-Wei Song, Chun-Jen Liu, Zhuo Li, Ping-Guo Liu, Cheng-Hao Huang, Yan Yan, Sheng-Xiang Ge, Ying-Bin Wang, Cheng-Yuan Peng, Jun Zhang*, Jia-Horng Kao, Ding-Shinn Chen, Pei-Jer Chen*, Ning-Shao Xia*. Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients. Gut, 2013; 62(1):182-184. 6、Chenguang Shen#, Junyu Chen#, Rui Li#, Mengya Zhang#, Guosong Wang#, Svetlana Stegalkina, Limin Zhang, Jing Chen, Jianli Cao, Xingjian Bi, Stephen F. Anderson, Timothy Alefantis, Minwei Zhang, Xiaoyan Cai, Kunyu Yang, Qingbing Zheng, Mujing Fan, Hai Yu, Wenxin Luo, Zizheng Zheng, Quan Yuan, Jun Zhang, James Wai-Kuo Shih, Harry Kleanthous, Honglin Chen, Yixin Chen*, Ningshao Xia*. A novel multimechanistic antibody targeting receptor-binding sites potently cross-protects against influenza B viruses since 1940. Science Translational Medicine, 2017; 9:eaam5752. 7、Qingbing Zheng#, Rui Zhu#, Longfa Xu#, Maozhou He#, Xiaodong Yan#, Dongxiao Liu, Zhichao Yin, Yangtao Wu, Yongchao Li, Lisheng Yang, Wangheng Hou, Shuxuan Li, Zizhen Li, Zhenqing Chen, Zhihai Li, Hai Yu, Ying Gu, Jun Zhang, Timothy S. Baker, Z. Hong Zhou, Barney S. Graham*, Tong Cheng*, Shaowei Li*, Ningshao Xia*. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nature Microbiology, 2019; 4:124-133. 8、Zhihai Li#, Shuo Song#, Maozhou He#, Daning Wang, Jingjie Shi, Xinlin Liu, Yunbing Li, Xin Chi, Shuangping Wei, Yurou Yang, Zhiping Wang, Jinjin Li, Huilian Qian, Hai Yu, Qingbing Zheng, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu*, Shaowei Li*, Ningshao Xia*. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nature Communications, 2018; 9:5360. 9、Longfa Xu#, Qingbing Zheng#, Shaowei Li#, Maozhou He, Yangtao Wu, Yongchao Li, Rui Zhu, Hai Yu, Qiyang Hong, Jie Jiang, Zizhen Li, Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Wei Wang, XianzZhong Ye, Jun Zhang, Timothy S. Baker, Tong Cheng*, Z. Hong Zhou, Xiaodong Yan*, Ningshao Xia*. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nature Communications, 2017; 8:505. 10、Rui Zhu#, Longfa Xu#, Qingbing Zheng#, Yanxiang Cui#, Shaowei Li#, Maozhou He, Zhichao Yin, Dongxiao Liu, Shuxuan Li, Zizhen Li, Zhenqin Chen, Hai Yu, Yuqiong Que, Che Liu, Zhibo Kong, Jun Zhang, Timothy S. Baker, Xiaodong Yan*, Z. Hong Zhou*, Tong Cheng*, Ningshao Xia*. Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Science Advances, 2018; 4:eaat7459. 11、Jason S. McLellan#, Man Chen#, M. Gordon Joyce#, Mallika Sastry#, Guillaume B. E. Stewart-Jones#, Yongping Yang#, Baoshan Zhang#, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou,Kevin W. Graepel, Azad Kumar, Syed Moin, Jeffrey C. Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa,Arjen Q. Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko,John-Paul Todd, Srinivas Rao, Barney S. Graham*, Peter D. Kwong*. Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus. Science. 2013; 342( 6158): 592-598. 12、Jason S. McLellan#*, Man Chen, Sherman Leung, Kevin W. Graepel, Xiulian Du, Yongping Yang,Tongqing Zhou, Ulrich Baxa, Etsuko Yasuda, Tim Beaumont, Azad Kumar, Kayvon Modjarrad,Zizheng Zheng, Min Zhao, Ningshao Xia, Peter D. Kwong*, Barney S. Graham. Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific NeutralizingAntibody. Science, 2013; 340(6136):1113-1117. 13、Mi Deng#, Xun Gui#, Jaehyup Kim#, Li Xie, Weina Chen, Zunling Li, Licai He, Yuanzhi Chen, Heyu Chen, Weiguang Luo, Zhigang Lu, Jingjing Xie, Hywyn Churchill, Yixiang Xu, Zhan Zhou, Guojin Wu, Chenyi Yu, Samuel John, Kouyuki Hirayasu, Nam Nguyen, Xiaoye Liu, Fangfang Huang, Leike Li, Hui Deng, Haidong Tang, Ali H. Sadek, Lingbo Zhang, Tao Huang, Yizhou Zou, Benjamin Chen, Hong Zhu, Hisashi Arase, Ningshao Xia, Youxing Jiang, Robert Collins, M. James You, Jade Homsi, Nisha Unni, Cheryl Lewis, Guo-Qiang Chen, Yang-Xin Fu, X. Charlene Liao, Zhiqiang An, Junke Zheng*, Ningyan Zhang*, Cheng Cheng Zhang*. Lilrb4 Signalling in Leukaemia Cells Mediates T Cell Suppression and Tumour Infiltration. Nature, 2018.562(7728):605-609. 14、夏宁邵,郑铁生.体外诊断产业技术.北京:人民卫生出版社,2018.获奖情况:1、2010年,戊型肝炎病毒优势构象性抗原决定簇的发现及在诊断中的应用,国家技术发明二等奖,排名第一;2、2001年,艾滋病毒重组抗原及第三代艾滋病毒抗体EIA诊断试,国家科技进步二等奖,排名第一;3、2017年,首届全国创新争先奖状;4、2012年,戊型肝炎病毒单克隆抗体及其用途,中国专利金奖,排名第一;5、2015年,原核表达类病毒颗粒疫苗研究团队,求是杰出科技成就集体奖,排名第一;6、2017年,传染病创新疫苗和诊断试剂的成果转化,药明康德生命化学研究奖首届科技成果转化奖;7、2013年,福建省科学技术重大贡献奖。
诊疗特色与专长
在疫苗、传染病检测技术等方面取得多项突破性成果。带领团队突破理论和技术障碍,创建出具有自主知识产权的大肠杆菌原核表达类病毒颗粒疫苗技术体系,藉此研制出全球首个上市的戊肝疫苗及即将上市的首个国产宫颈癌疫苗,开辟了基因工程疫苗研发的新途径;发明的戊肝诊断试剂被公认为新一代国际“金标准”;研制出多个质量领先的艾滋病毒诊断试剂,两次引领国产艾滋病免疫诊断试剂升级换代,使国产艾滋病诊断试剂长期维持在国际先进水平。
社会/学术任职
担任国家科技计划战略咨询与综合评审特邀委员会委员、国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”总体专家组成员、第七届教育部科技委生物与医学学部委员、全国体外诊断产业技术创新战略联盟理事长、中国医师协会临床精准医疗专业委员会第一届委员会常务委员、中华预防医学会感染性疾病防控分会第一届委员会顾问。
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